The Maserati Quattroporte was initially offered in only one configuration, equipped with an automated manual transmission, marketed as DuoSelect. The base Quattroporte DuoSelect featured a chrome grille with horizontal slats, adaptive suspension, marketed as Skyhook and 330 mm brake disks with four piston calipers at each wheel. Maserati offered fifteen exterior paint colours, Poltrona Frau leather upholstery in ten colours, contrasting seat piping and stitching and three types of wood inserts.

In 2004, the American luxury department store Neiman Marcus offered a limited edition of the Quattroporte, only available for order through the retailer's 2004 Christmas Catalog at a price of 125,000 USD. Each of the 60 Neiman Marcus Quattroportes was finished in Bordeaux Pontevecchio (wine red) exterior colour and featured a chrome mesh-front grill along with side vents and 19-inch ball-polished wheels. The interior was upholstered in ivory Poltrona Frau leather accented with Bordeaux piping and mahogany wood trim.[50][51]

At the Frankfurt Motor Show in September 2005, Maserati introduced two different trim levels for the Quattroporte, the Executive GT and Sport GT